Cannabis cells interact with the body's endocannabinoid system, which plays a role in pain modulation. It can potentially reduce the perception of pain, particularly chronic pain, neuropathic pain, and pain associated with inflammation.

THC has antiemetic properties, meaning it can help reduce nausea and vomiting. This is particularly helpful for people undergoing chemotherapy or experiencing other conditions that cause severe nausea. Synthetic THC medications (e.g., dronabinol, nabilone) are already approved for this purpose.

THC is well-known for increasing appetite, often referred to as "the munchies." This can be beneficial for individuals experiencing appetite loss due to medical conditions such as HIV/AIDS, cancer, or eating disorders. It can help improve food intake and prevent malnutrition.

It can promote relaxation and reduce anxiety, which can lead to improved sleep quality. The effects are highly individual, and the optimal dose and strain may vary. Long-term use can sometimes lead to tolerance and sleep disturbances

Some preclinical research suggests that THC may have neuroprotective properties, meaning it could protect brain cells from damage. This is thought to be related to its antioxidant and anti-inflammatory effects. However, this research is still in its early stages, and more studies are needed to confirm these effects in humans. The long-term effects of THC on brain health are still being investigated.